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We sought to
assess
the
relation
between
the
sex
and
phenotype
of
affected
probands
and
the
sex
of
affected
first-degree relatives
.
本研究评估受影响的先证者的性别、表现型和受影响的第一亲代性别之间的关系。
In
female
probands
,
maternal
stroke
was
80%
more
likely
than paternal stroke
,
whereas
in
male
probands
,
no
gender
difference
was
seen
.
在女性先证者中，母亲中风比起父亲中风的几率高80%，而在男性先证者中，没有观察到性别差异。
The
probands
father
carried
the
mutation
.
先证者的父亲携带该致病突变基因。
9
deletions
male
ones
of
29
high-risk
fetuses
were detected,
who
had the
same
deletion
-
segments
as
their
probands
.
29例高危胎儿中9例男性胎儿为缺失型，缺失位点与先证者相同。
No
base
alterations
were
found
compared
to
the
Gene
Bank
in the
6
probands
.
6个先证者的PCR产物测序结果与基因组序列相比对，也未发现碱基改变。