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Ranolazine
雷诺嗪
常用释义
词性释义
雷诺嗪
例句
全部
雷诺嗪
Although
several
pharmacological
activities
of
ranolazine
have
been
described
,
the
precise
way the
drug
works
is
not
fully
understood
.
尽管已经说明了雷诺嗪的一些药理活性,但是该药的确切作用机制仍未完全了解。
Conclusion
Ranolazine
can inhibit the
fast
sodium
channel
current
in
rabbit
atrial
myocytes
and
indeed
has
a use-dependent
effect
.
结论雷诺嗪对兔心房肌细胞快钠电流有一定的抑制作用,其存在使用依赖性阻滞作用。
The FDA
also
warned
that
use
of
ranolazine
is
contraindicated
in
patients
with
clinically
significant
hepatic
impairment
.
美国食品和药物管理局还警告说,雷诺嗪不适于临床诊断为肝损害的患者使用。
For
patients
taking
moderate
CYP3A
inhibitors
,
ranolazine
dosing
should
be
limited
to
500 mg
twice
daily
.
患者在服用中度CYP3A抑制剂时,雷诺嗪剂量应限制在500mg内,每天两次。
METHODS
Ranolazine
was
synthesized
by
using
2
,
6
-dimethylaniline and guaiacol
as
the
starting
material
fellewed by
4
step
reactions
.
方法以2,6-二甲基苯胺、愈创木酚为原料,经酰化、烃化等4步反应制得雷诺嗪。
Chiral
Separation
of
Ranolazine
Hydrochloride
Enantiomers
by
Reversed
-
phase
High Performance Liquid
Chromatography
盐酸雷诺嗪对映体的反相高效液相色谱手性分离
Direct
chiral separation of
racemic
ranolazine
by
high performance
liquid
chromatography with chiral
stationary
phase
高效液相色谱手性固定相法直接拆分外消旋雷诺嗪
Improved
synthesis
of a
novel
antianginal
agent
ranolazine
新型抗心绞痛药物雷诺嗪的合成工艺改进
Ranolazine
Improves
Exercise
Tolerance
in
Chronic
Angina
雷诺嗪可改善慢性心绞痛患者的运动耐量
Study
on
Synthesis
Process
of
Ranolazine
雷诺嗪的合成工艺研究
1·ChinaABSTRACT: Objective To explore the effect of ranolazine on the fast sodium channel current (ina) in rabbit atrial myocytes and the existence of use-dependent blockade.
目的研究雷诺嗪对兔心房肌细胞快钠电流的影响及其是否存在使用依赖性阻滞作用。