1·Objective: To optimize the preparation procedure of aripiprazole.
目的:优化阿立哌唑的制备工艺。
2·Objective: To observe the efficacy and safety of small doses of aripiprazole in the treatment of attention deficit and hyperactive disorder (ADHD).
目的:观察小剂量阿立哌唑治疗注意缺陷与多动障碍(ADHD)的临床疗效及不良反应。
3·CONCLUSION Combined a low dose aripiprazole to long term treatment for schizophrenia patient antipsychotics-induced hyperprolactinemia is effective and safe.
结论:合并小剂量阿立哌唑治疗抗精神病药所致高催乳素血症的长期效应好,安全性高。
4·Conclusion Both of Aripiprazole and Risperidone show good effect and less side effects on Schizophrenia, so we can choose anyone according to curative effect and reaction degree.
结论阿立哌唑与利培酮治疗精神分裂症疗效均好、副反应少,可根据疗效和反应程度不同选择使用。
5·Aripiprazole in overall yield of 68% was synthesized from 2, 3-dichloroaniline by a three-step nucleophilic substitution reaction in yield of 83%, 91% and 90%, respectively.
以2,3 -二氯苯胺为原料,经3步亲核取代反应合成了阿立哌唑。3步反应的收率分别为83%,91%和90%;总收率68%。