1·AIM: To study the pharmacokinetics of leflunomide in Chinese healthy volunteers.
目的：研究来氟米特在中国健康志愿者的药代动力学。
2·Conclusion Leflunomide can improve immune status and renal function of BXSB lupus mice, and delay their disease progression.
结论来氟米特可显著改善BXSB小鼠的免疫状况和肾脏功能，能延缓BXSB狼疮鼠的疾病进程。
3·The metabolism experiment in rabbit skin showed that leflunomide can be partly metabolized in skin and a further study should be carried out to investigate the metabolism mechanisms.
皮肤代谢实验结果表明来氟米特在兔皮肤中能被部分代谢，其代谢机制有待进一步研究。