1·Objective To investigate the effects of fenofibrate on E-selectin and intercellular adhesion molecule-1 (ICAM-1) secretion of the endothelial cells.
目的研究非诺贝特对内皮细胞产生E-选择素和细胞间黏附分子1（ICAM-1）的影响。
2·Objective: To investigate the effect of fenofibrate on the expression of adiponectin gene, the level of the plasma adiponectin and endothelial function in diabetic rats.
目的：观察非诺贝特对糖尿病大鼠血脂联素和脂联素基因的表达及内皮细胞功能的干预作用。
3·The study also found that people in the fenofibrate group had a 47 percent lower risk of amputations below the ankle and without large-vessel disease in the amputated limb.
研究还发现非诺贝特组踝以下截肢风险降低47%，所截肢内无大血管病变。
4·The risk of a first amputation was 36 percent lower among people taking fenofibrate than those taking the placebo.
初次截肢的风险非诺贝特组较安慰剂组降低了36%。
5·Conclusion: Fenofibrate can inhibit high glucose-induced proliferation of mesangial cells, decrease synthesis of extracellular matrix, and increase degradation of extracellular matrix.
结论：非诺贝特能抑制高糖培养的系膜细胞增殖，减少胞外基质合成，增加胞外基质的降解。