1·Conclusion Celecoxib may reduce the accumulation of prostaglandin E2 by inhibiting cyclooxygenase-2 activity, and thus inhibiting the expression of VEGF.
结论塞来昔布可能通过抑制环氧化酶2活性，减少前列腺素e2在大脑皮质中聚集，而抑制VEGF的表达。
2·Objective to investigate the effect of celecoxib on the cyclooxygenase-2 (COX-2) expression and the growth of orthotopic transplantation tumor in the case of experimental colorectal cancer.
目的探讨塞来昔布对实验性结肠癌原位移植瘤生长及环氧化酶- 2 (COX - 2)表达的影响。
3·They also found that celecoxib blocked exogenous interleukin-6-induced STAT3 phosphorylation and nuclear translocation.
同时，他们还发现，塞来昔布阻断外源性白介素诱导的STAT 3磷酸化及核转位。
4·Therefore, we believe that celecoxib can be combined with other anticancer drugs to reduce drug resistance caused by interleukin-6 STAT3 signals.
因此，我们推测通过联合塞来昔布可以降低化疗药耐受现象的发生。